Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials

When a candidate predictive marker is available, but evidence on its predictive ability is not sufficiently reliable, all‐comers trials with marker stratification are frequently conducted. We propose a framework for planning and evaluating prospective testing strategies in confirmatory, phase III marker‐stratified clinical trials based on a natural assumption on heterogeneity of treatment effects across marker‐defined subpopulations, where weak rather than strong control is permitted for multiple population tests. For phase III marker‐stratified trials, it is expected that treatment efficacy is established in a particular patient population, possibly in a marker‐defined subpopulation, and that the marker accuracy is assessed when the marker is used to restrict the indication or labelling of the treatment to a marker‐based subpopulation, ie, assessment of the clinical validity of the marker. In this paper, we develop statistical testing strategies based on criteria that are explicitly designated to the marker assessment, including those examining treatment effects in marker‐negative patients. As existing and developed statistical testing strategies can assert treatment efficacy for either the overall patient population or the marker‐positive subpopulation, we also develop criteria for evaluating the operating characteristics of the statistical testing strategies based on the probabilities of asserting treatment efficacy across marker subpopulations. Numerical evaluations to compare the statistical testing strategies based on the developed criteria are provided.     

农村互助型社会养老:中国特色与发展路径

农村互助型社会养老是具有中国特色的社会养老的发展形式，是对农村传统家庭养老的重要补充。它扎根于农村传统的亲邻互助网络，其本质在于经济互助，表现为有组织地发动邻里、志愿等社会力量，充分利用以老年人为主的各类人力资源的闲置时间、资源低成本地相互帮助和服务。社会各界应将其作为重要实施方略，纳入积极应对人口老龄化战略和乡村振兴战略之中。其发展路径可以概括为：以资金互助为基础，以组织动员为抓手，以服务互助为重点，以社区居家养老为主要阵地，创新各类互助养老模式，着力形成稳定多元的资金来源，培育互助队伍，增加互助内容，从无偿到无偿、低偿相结合，探索建立标准规范的服务管理评估制度，机构养老与社区居家养老互联互通，最终尝试建立圈层化、整合化、网络化、制度化的农村互助型社会养老体系。     

谁的乡村建设？——基于乡村建筑变迁的观察和思考

在全面推进乡村振兴的大背景下，乡村建设正如火如荼地开展。其中，乡村建设中农民房屋建筑类型从特质性的“匠心独具”到同质性的“千村一面”，再到异化性的“自厝同异”变迁路径，反映出传统文化的保护危机，也深刻揭示出建筑变迁背后暗藏的农民与地方政府间的多元矛盾和博弈。此问题的根源在于农民主体性被消解，成了被建构的对象或客体，而地方政府却不断强化构建主体的身份认同。事实上，当前乡村建设呈现出五种不同的价值取向：一是为城市消费者休闲情趣的乡村建设；二是为城市中产阶级家乡情感的乡村建设；三是为地方政府凸显政绩的乡村建设；四是为开发商投资回报的乡村建设；五是为农民生存利益的乡村建设。不同参与者均带着不同的利益诉求介入乡村建设，直接影响到乡村建设的发展走向。因此，要处理乡村建设中的矛盾和问题，必须强化农民在乡村建设中的主体意识和主体身份，赋予农民对乡村建设事务的话语权与决定权。     

Portrayals of the internal God among Ashkenazi Jewish Orthodox lesbians in Israel

Abstract

Most of the existing literature on Ashkenazi Orthodox Jewish lesbians focuses on sociological aspects, mainly the negative attitudes held by religious communities towards their sexual identity and the various problems that arise from these. Less attention has been paid to lesbians’ psychological coping mechanisms with the tensions between their two central identities: the religious and the sexual. Ashkenazi Orthodox lesbians find themselves in a complicated situation where they remain on the margins of both their “natural” communities: the religious one and the homosexual one. As a result, they feel rejected, isolated, and even punished by society. As believers, God is their ultimate refuge. But there are different conceptions of God, ranging from benevolent to persecutory, accepting or highly judgmental and punishing. This variance has not been considered in regard to the dual identity of Ashkenazi Orthodox lesbians. This article focuses on this neglected issue, examining Ashkenazi Orthodox lesbians’ conception of God and its relation to their managing the conflict between their apparently conflicting identities.     

Participatory shaping of community futures in e‐waste processing hubs: Complexity,conflict and stewarded convergence in a Palestinian context

This article describes an unconventional participatory development approach carried out in an informal e‐waste hub in South‐West Hebron, an area that has collected and processed the bulk of Israeli e‐waste for over a decade. Our approach contributes to the critique and recovery of community representation in participatory development and the search for ways to facilitate representative community engagement. Specifically, we describe our use of a novel Delphi‐like method that allowed us to facilitate a broadly endorsed development trajectory within a heterogeneous and conflicted community. We show how the results yielded by this approach diverged from those that were likely to emerge from more facile forms of participation in ways that are important for other similar e‐waste hubs internationally, which face a destructive status quo on the one hand, or the economically ruinous international policies that ban e‐waste trade from “developed” to “developing” countries on the other. Despite real tensions and cleavages within the affected communities, the process described facilitated a shift from deadlocked environmental versus livelihood positions towards building capacity and regulating existing informal e‐waste trades to preserve livelihoods dependent on these.     

Industrial relations and adjustments to the crisis: A comparative micro‐statistical analysis of France and Great Britain

In this comparative study, the authors analyse the relationships between industrial relations and workforce or wage adjustments in response to the 2007–08 crisis, using two highly comparable establishment‐level surveys conducted in Great Britain (WERS) and France (REPONSE) in 2010–12. Notwithstanding contextual differences in the countries’ productive systems and the timing and impact of the crisis, the relationships between industrial relations and adjustment strategies appear to have been similar (trade union presence not preventing adjustments). Differences in industrial relations are therefore not found to provide an explanation for the different modes of adjustment observed at the macroeconomic level.     

基于SWOT模型的农村地区学前教育发展问题研究

SWOT分析法又称作态势分析法，能够将内部的优势劣势、外部的机会威胁逐条列举出来，并据此建立可视化矩阵图，系统全面地提出针对性策略。学前教育作为基础教育的短板，而农村地区学前教育又是学前教育中的短板。借助SWOT模型系统，全面地分析了农村地区学前教育发展的内部与外部的优势（S）、劣势（W）、机会（O）和威胁（T），进而提出相应的增长型战略、扭转型战略、多元化战略和防御型战略，以促进农村地区学前教育平稳、健康发展。     

‘Surrounded with so much uncertainty’: asylum seekers and manufactured precarity in Australia

In Australia, nearly 30,000 asylum seekers have the legal right to work, but their temporary and conditional migration status exposes them to work-related precarity. This article draws on a small qualitative study that examined asylum seekers’ experiences of seeking work and achieving economic security. Over an 18-month period, 29 semi-structured interviews with asylum seekers who had work rights in Australia were conducted. It provides insights into how restrictive immigration policies manufacture precarity through short-term, conditional visas, resulting in employer risk aversion, segmentation into insecure work, and in-work instability and mistreatment. Asylum seekers manage their experiences and feelings of pervasive insecurity through individual coping and survival strategies.     

Agency and fatalism in older Appalachian women’s information seeking about gynecological cancer

Researchers consider older women in rural Appalachia to have low levels of agency and high levels of fatalism regarding decision making about cancer treatment. Using the life course perspective, we examined older women’s agency with information seeking about gynecological cancer. Semistructured interviews with 20 White women living in central Appalachia revealed four trajectories: Surrendering Control, Accepting Death, Self-Care, and Advocacy, each with its own forms of agency. Some women experienced personal transformation, increased self-efficacy, and a passion for community empowerment. Fatalism was not understood apart from placing trust in medical expertise. We implore researchers to further explore rural expressions of agency.